By Harry Adelson - USA


Introduction to MesoGlow

In France, one of the most popular aesthetic applications of mesotherapy is the “MesoGlow” for the skin of the face and neck. In the US Mesotherapy for the face has been marketed as the “MesoLift”, a “non-surgical face-lift”, but this is not entirely accurate. The MesoGlow is the administration of hyaluronic acid, multivitamins and minerals, a vasodilatory medication, and a local anesthetic using mesotherapeutic injection techniques to the skin of the face, neck, chest or hands.

Hyaluronic acid is a major component of human skin and is largely responsible for maintaining hydration of the skin. As we age, the levels of hyaluronic acid diminishes and this one of the major culprits in the visual appearance of aging skin. Similarly, levels of antioxidant vitamins and minerals and microcirculation of the skin diminish which furthers skin ageing. The MesoGlow, then is the mesotherapeutic infusion of substances into the skin which have a rejuvenating and dehydrating effect. It is extremely safe, and is a terrific addition to Botox and fine line treatment with cosmetic fillers

Indications/Contraindications for MesoGlow

Very simply, the MesoGlow is intended as a rejuvenation and rehydration treatment for the skin. We are not as strict with our patient selection as we are with the fatty deposit/cellulite treatment, however patients with bleeding disorders, infections, skin disease or known allergies or sensitivities to the substances used should not received the MesoGlow. Although it can be performed anywhere on the body, it is most commonly done on the face, but can be done on the neck, chest and hands as well. It will not eliminate sagging skin, pigmentation irregularities, pock marks, scars, acne or any type of dermatitis and should not be performed on patients with active skin disorders. It is meant solely to give ageing skin a youthful glow (hence the term, MesoGlow). Patients on anti-coagulant therapies (including aspirin) should not receive the MesoGlow unless the physician feels it is reasonably safe to discontinue the therapy for a couple of days before the treatment. This is because patients on anti-coagulant therapy bleed too much which makes the procedure take many times longer to perform. Further, these patients are at a much higher risk of significant bruising.

Materials Used for MesoGlow

For the MesoGlow, we use standard 5cc Luer Loc syringes, and 30 gauge needles of both 4mm and 12mm length. We use disposable hair nets and chucks to protect the patient’s hair and clothing from being stained with the B-vitamins in the solution. We have ample cotton balls or gauze pads available.

Some mesotherapists will use an electronic injecting gun, but for the purpose of this video, we will use the manual technique. 

Formulas used:

In a 5cc syringe we draw up 1cc of each of the following:
Lidocaine 2% (without epinephrine)
Pentoxifylline 20mg/ml
Hyaluronic Acid 10mg/ml
A Broad Spectrum, Highly Concentrated Multi Vitamin and Mineral Solution

Hyaluronic Acid (sodium hyaluronate)
Sodium hyaluronate is a viscous solution consisting of a high molecular weight (500,000-730,000 daltons) fraction of purified natural sodium hyaluronate in buffered physiological sodium chloride. Sodium hyaluronate is extracted from rooster combs and can therefore be considered a natural substance (it’s chicken). Hyaluronic acid is a natural complex sugar of the glycosaminoglycan family and is a long-chain polymer containing repeating disaccharide units of Na-glucuronate-N-acetylglucosamine. Contraindicated in patients with known hypersensitivity to hyaluronate preparations. Avoid the use of disinfectants containing quatemary ammonium salts for skin preparation because hyaluronic acid can precipitate in their presence. Anaphylactoid and allergic reactions have been reported with this product and the performance of a skin test is considered “best practice”. A skin test is the intradermal injection of approximately 0.02 ml of the solution. A positive reaction consists of a wheal with pseudopods appearing within five minutes and persisting for 20 to 30 minutes and accompanied by localized pruitis. Transient vasodilation at the site of the test, (erythema), will may occur and is not a positive reaction.

Description of MesoGlow Procedure

We have the patient thoroughly wash their face with soap and it is paramount to instruct the patient to not apply creams, lotions or make up. Patients can either arrive to the clinic as such, or they can arrive early and wash their face in-office. You can offer the patient an anesthetic cream, but it is not necessary as the procedure is minimally uncomfortable. The needle entering the skin generally does not hurt, but the injection of the vitamin C containing solution feels like a mild bee sting, and we have found that the anesthetic creams do not help with this. Should you choose to use an anesthetic cream, it is necessary to apply it liberally and leave in place for at least 20 minutes before the MesoGlow.

We lay the patient supine; place the disposable hair net on the patient’s head and the chuck completely covering the patient’s clothing around their neck. We wipe the face thoroughly with alcohol soaked cotton balls or gauze. We are now ready to treat.

We start first with the 4mm needle and use a “point by point” technique. We gently pinch up a fold of skin and quickly insert the needle. We have found that if the needle tip is free of a drop of solution, the needle entering is more comfortable. We then inject approximately 0.05cc of solution. We cover the entire area to be treated in this manner in a grid pattern at 1-2cm intervals. We avoid injecting into visible superficial vasculature, but we will inevitably nick superficial vasculature not visible. This will cause bleeding and it is important to immediately apply pressure and maintain pressure until bleeding stops to decrease the likelihood of a bruise. Because of the need to pinch the skin and inject between the fingers, especially on the forehead, this technique is one of the more dangerous ones as far as the likelihood of an inadvertant “stick” to the mesotherapists. Be careful and take your time.

Once we have completed the “point by point” section of the treatment, we then remove the 4mm needle and place the 12mm needle onto the syringe. We are now going to use the “epidermic” technique. As the name implies, this is the most superficial of the techniques, and the needle does even puncture the skin. The 12mm needle, bevel up and at a very steep angle (aproximatnly 160 degrees) is dragged along the skin while light positive pressure is applied to the syringe’s plunger. The needle will bend slightly from the angle and the pressure. In the treatment of painful conditions, some practitioners will use a slight bouncing action additionally which will cause minor pin-point bleeding, but this is not recommended in the MesoGlow due to the risk of scaring. Epidermic technique will cause a shallow groove in the uppermost layers of ketatinized epithelial cells and place a bead of solution into that groove. When done correctly, there is no bleeding, but one is able to see the solution quickly absorb into the skin. Epidermic technique is done in a grid pattern at 1cm intervals. Care must be taken, if the epidermic technique is applied to aggressively, it can leave scars.

We then leave the solution to penetrate into the skin for 5 minutes or so.

We then wipe away any residual solution or blood and apply vitamin A oil and gently massage it into the face. If your clinic offers any type of mask treatments, this is the ideal time to perform one.

Overview of Treatment Protocol

MesoGlow in France is recommended once per week for three weeks, then every other week for a month for a total of 5 treatments. The results are not permanent and the protocol can be repeated every six months or so.

Patient Education/Preparation

The term “MesoLift” has been used by other physicians in aggressive marketing campaigns. This term is misleading, because mesotherapy will not treat sagging skin. It is imperative that it be explained that MesoGlow is a more accurate name for the procedure, because it gives the skin a youthful glow by rehydrating and infusing antioxidants and vasodilators.

As was mentioned, patients must be treated having washed their face with soap and not apply creams, lotions or make-up.

The only associated risk that must be conveyed to patients is the risk of bruising. These bruises are generally very small and quickly disperse. Application of heat can be of help to make them disappear more quickly. There is risk of scaring if the epidermic technique is performed too aggressively, but with proper technique, this should never be encountered. 

After treatment, it is helpful to apply vitamin A/K cream and lightly massage it into the skin to help prevent bruising. If your clinic offers any type of mask treatments, this is the ideal time to perform one. Patients must be instructed to not apply any creams, lotions or make up for several hours after the procedure to reduce the risk of infection.

Harry Adelson

By Harry Adelson

Dr Adelson - the only American Faculty Member of the French Society of Mesotherapy who has approved this text.

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FACE ANTIAGING is a sterile biological solution created for facial rejuvenation, hydration, toning and revitalization. It comprises nutritional, structural and metabolic elements essential for optimum skin regeneration and repair. The formulation, which includes vitamins, minerals, enzyme co-factors, hyaluronic acid and nucleic acid precursors. is presented as a single use sterile vial and contains the optimum proportions of each component required for skin cell metabolism.

FACE ANTIAGING can be used as a stand alone treatment or immediately following a glycolic acid mask or peel. The results will be enhanced and skin healing improved.

Hyaluronic acid, DMAE and other structural and physiological components for the skin (vitamins, minerals, oligoelements, nucleicacids, co-enzymes, aminoacids)


Basic antiaging, revitalising, moisturising, restructuring and anti-looseness treatment for the skin and anti-wrinkle treatment for the middle and lower face, throat and neck. Sagging and wrinkled areas due to lack of muscle tone.

How to apply:
1. SKIN TOLERANCE TEST a few days prior to the session.
2. Completely disinfect the area
3. Apply anaesthetic cream to the area to be treated or mix equal parts in the syringe with the usual anaesthetic (Procaine or Lidocaine).
4. Prepare the required dose in the syringe with a 30 G ½. needle
5. Make papules following the path of the wrinkle by allowing practically only the tip of the needle to enter. Deposit a minimum quantity of
the product into the papule with the tip of the needle facing upwards.
6. Perform the same over the anaesthetised face area in a grid pattern until the whole facial area has been covered.
7. Completely disinfect the area
8. As an option, apply a layer of Post – Depil Simildiet (calming, relaxing, anti-edematose, anti-inflammatory and scar healing) for 15 minutes. Slightly drain until the Post – Depil has been fully absorbed.

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Disclaimer and terms of issue: The information in this website has been compiled with all care, however the reader accepts the authors intention is not to provide any medical advice of any kind .The onus & responsibility of the application of any of the suggestions made in this website lies with the reader in consultation with a qualified medical practitioner. The practice of Mesotherapy or any medical application should be done under the strict supervision of a registered & qualified medical practitioner. Patients should be thoroughly examined prior to any treatment & closely monitored after it's commencement.